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Empirical evidence indicates that paclitaxel administration can result in axonal degeneration, demyelination, and alterations in oligodendrocyte function, collectively leading to disruption of white matter architecture and functionality ( 10 Impaired mitochondrial function Mitochondria, which are far more abundant than energy producers, are central regulators of synaptic plasticity, learning, and memory ( Paclitaxel impairs mitochondrial function through multiple mechanisms, leading to cognitive dysfunction

Gilmore LA, Klempel-Donchenko M, Redman LM

We hypothesize that (i) the slow inhibition observed in the biochemical assay with the recombinant protein with some of the compounds is due to their preferential binding to a slowly populated conformer of the NADP + -TGR(H) complex and (ii) this conformer is already populated in the worm cell interior accounting for the more rapid inhibition of TGR observed in ex vivo worms with the slow inhibitors

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